A Case of Woringer-Kolopp Disease of the Hand / 대한피부과학회지
Korean Journal of Dermatology
;
: 552-556, 2016.
Article
in Korean
| WPRIM
| ID: wpr-12167
ABSTRACT
Woringer-Kolopp disease, also known as localized pagetoid reticulosis, is a rare variant of mycosis fungoides that presents as a solitary localized hyperkeratotic patch or plaque on the extremities and follows a benign course. Effective treatments for Woringer-Kolopp disease include skin-directed therapies such as topical nitrogen mustard, high-potency topical steroids, and phototherapy. Surgical excision has been pursued in cases of small, localized lesions. A 39-year-old man presented with a 3-month history of an asymptomatic plaque on his hand. Physical examination showed a 10-mm-diameter solitary round erythematous hyperkeratotic plaque with a slightly raised edge on the dorsum of his left hand. A skin biopsy revealed that numerous atypical lymphocytes had infiltrated the upper dermis and expanded into the epidermis with a pagetoid pattern. These atypical pagetoid cells were strongly positive for CD3, CD8, and T-cell intracellular antigen-1; focally positive for CD4; and negative for CD20, CD30, and CD56. A subsequent general examination revealed no evidence of systemic involvement and the lesion was treated with surgical excision. Here we report a rare case of Woringer-Kolopp disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phototherapy
/
Physical Examination
/
Skin
/
Steroids
/
Biopsy
/
Lymphocytes
/
T-Lymphocytes
/
Mycosis Fungoides
/
Dermis
/
Epidermis
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2016
Type:
Article
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