Antimicrobial Susceptibility Patterns of Legionella isolates in the Environment and in Patients / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
; : 28-33, 2010.
Article
in Ko
| WPRIM
| ID: wpr-121790
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Antimicrobial susceptibility of Legionella spp. has rarely been studied in Korea. Therefore, we aimed to determine the susceptibility of Legionella spp. to various antibiotics. METHODS: We assessed the antimicrobial susceptibility of 66 environmental and clinical Legionella isolates collected between January 2001 and December 2008 from Korea and Japan. The minimum inhibitory concentrations (MICs) of 6 antibiotics, namely, azithromycin, ciprofloxacin, clarithromycin, clindamycin, gatifloxacin, and gemifloxacin were determined by the broth microdilution method using buffered starch yeast extract broth. RESULTS: The MIC ranges of the 6 antibiotics used against the Legionella isolates were as follows: 0.004-0.062 microgram/mL (azithromycin), 0.002-0.5 microgram/mL (ciprofloxacin), 0.004-0.5 microgram/mL (clarithromycin), 0.12-4 microgram/mL (clindamycin), 0.002-0.12 microgram/mL (gatifloxacin), and 0.008-1 microgram/mL (gemifloxacin). CONCLUSIONS: Legionella spp. isolates from Korea and Japan were most susceptible to gatifloxacin. Azithromycin, clarithromycin, ciprofloxacin, and gemifloxacin were also effective for treating legionellosis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Legionellosis
/
Legionella
/
Clindamycin
/
Ciprofloxacin
/
Microbial Sensitivity Tests
/
Clarithromycin
/
Azithromycin
/
Fluoroquinolones
/
Drug Resistance, Bacterial
/
Anti-Bacterial Agents
Limits:
Humans
Language:
Ko
Journal:
The Korean Journal of Laboratory Medicine
Year:
2010
Type:
Article