A case of hypophosphatemic osteomalacia associated with low-dose adefovir dipivoxil treatment / 대한내과학회지
Korean Journal of Medicine
;
: 261-265, 2010.
Article
in Korean
| WPRIM
| ID: wpr-121796
ABSTRACT
Adefovir dipivoxil (ADV) effectively inhibits lamivudine-resistant hepatitis B virus replication. Hypophosphatemia and elevated serum creatinine are ADV-related nephrotoxicity caused by high-dose ADV. Hypophosphatemic osteomalacia is very rare and is induced by low-dose ADV. A 61-year-old man suffering from chronic hepatitis B manifested with generalized myalgia and bone pain, especially in both ankles and knees. He had been administered ADV for 56 months, since lamivudine-resistant HBV was detected. He developed severe hypophosphatemia and elevated serum alkaline phosphatase levels with a high bone fraction. Bone densitometry and a whole-body bone scan revealed osteoporosis and multiple hot uptake lesions. Blood chemistry and clinical symptoms improved after discontinuing the ADV.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteomalacia
/
Osteoporosis
/
Stress, Psychological
/
Adenine
/
Hepatitis B virus
/
Hypophosphatemia
/
Hepatitis B, Chronic
/
Creatinine
/
Densitometry
/
Alkaline Phosphatase
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2010
Type:
Article
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