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The effect of continuous glucose injection on preventing hypoglycemia during hemodialysis / 대한내과학회지
Korean Journal of Medicine ; : 642-647, 2002.
Article in Korean | WPRIM | ID: wpr-122001
ABSTRACT

BACKGROUND:

Hypoglycemic episodes in patients under hemodialysis have been known to be caused by the removal of glucose through dialyzer membrane and is one of the important factors causing discomfort, especially in patients with diabetes. We studied frequency of hypoglycemia, characteristics of patients and their underlying disease and changes of glucagon and cortisol levels during dialysis. We also studied whether continuous glucose injection could prevent hypoglycemic episodes during dialysis with dialysate lacking glucose.

METHODS:

Forty-four patients under hemodialysis treatment were enrolled. All patients were observed for 5 sessions of dialysis before enrolled in glucose injection therapy. Their blood were collected at time 0, 2 and 4 hours after starting final session of dialysis. After one month, blood samples were collected at the same time interval during dialysis with continuous glucose injection (50% glucose solution, 12.5 g/h).

RESULTS:

Twenty-two patients (DM 12 patients, non-DM 10 patients) showed their blood glucose level less than 60 mg/dL during dialysis. Among these patients, 3 patients did not complain any hypoglycemic symptoms. No patient showed hypoglycemia under continuous glucose injection during dialysis. Frequency of random glucose injection according to patients' complaint was significantly decreased during continuous glucose injection. Urea reduction rate was not affected by glucose injection. There was no significant difference in patients' characteristics and their underlying diseases, basal and amount of changes of glucagon and cortisol concentration during dialysis regardless episode of hypoglycemia.

CONCLUSION:

Hypoglycemic episode during hemodialysis occurs as frequently in non-diabetic patients as in diabetic patients. Continuous glucose injection could be an effective and convenient method to prevent hypoglycemia during hemodialysis in both diabetic and non-diabetic patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Urea / Blood Glucose / Glucagon / Hydrocortisone / Renal Dialysis / Diabetes Mellitus / Dialysis / Glucose / Hypoglycemia / Membranes Limits: Humans Language: Korean Journal: Korean Journal of Medicine Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Urea / Blood Glucose / Glucagon / Hydrocortisone / Renal Dialysis / Diabetes Mellitus / Dialysis / Glucose / Hypoglycemia / Membranes Limits: Humans Language: Korean Journal: Korean Journal of Medicine Year: 2002 Type: Article