The Effects of Intrathecal Neostigmine on Postoperative Analgesia in Patients Undergoing Total Knee Replacement / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 121-125, 1998.
Article
in Korean
| WPRIM
| ID: wpr-12206
ABSTRACT
BACKGROUND:
Intrathecal neostigmine causes analgesia in dose-dependent pattern. This study was designed to examine postoperative analgesia with intrathecal neostigmine in a randomized, blinded trial with tetracaine as the active control in patients undergoing total knee replacement (TKR).METHODS:
Eighty patients scheduled for TKR were divided into seven groups ( Control; no neostigmine, N25, 50, 75, 100, 125 and 150; subarachnoid tetracaine with neostigmine 25, 50, 75, 100, 125 and 150 g, respectively). Postoperatively, patients assessed their pain on a 10-cm visual analog scale (VAS), total analgesic requirement, time to first analgesic rescue medication and side effects were assessed.RESULTS:
Increasing doses of intrathecal neostigmine showed a dose-dependent pattern of analgesia defined by the overall VAS scores, time until first administration of rescue analgesic request, and the number of rescue analgesics (p<0.05). Nausea and vomiting was also increased by increasing doses of intrathecal neostigmine (p<0.05).CONCLUSIONS:
Intrathecal neostigmine with tetracaine produced definitive analgesia in patients undergoing TKR, and neostigmine 75 g resulted in a better analgesic effect with fewer side effects than other doses.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tetracaine
/
Vomiting
/
Arthroplasty, Replacement, Knee
/
Visual Analog Scale
/
Analgesia
/
Analgesics
/
Nausea
/
Neostigmine
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1998
Type:
Article
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