A Case of Isolated Traumatic Caudate Lesion with Marked Improvement in Visuospatial Function by Donepezil

ABSTRACT

Visuospatial dysfunction after isolated caudate lesion and improvement by donepezil has not been reported. Herein we report a 46-year old woman with visuospatial dysfunction after an isolated traumatic caudate lesion. Memory impairment and visuospatial dysfunction with normal frontal executive functioning was found in the first neuropsychological test. Her brain MRI showed an isolated right caudate lesion in the dorsal portion. Donepezil was prescribed. On follow-up neuropsychological testing, memory and visuospatial function increased by more than 100% from the base line.