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Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma
Experimental & Molecular Medicine ; : 622-629, 2011.
Article in English | WPRIM | ID: wpr-122147
ABSTRACT
Platelet-rich plasma (PRP) contains growth factors that promote tissue regeneration. Previously, we showed that heparin-conjugated fibrin (HCF) exerts the sustained release of growth factors with affinity for heparin. Here, we hypothesize that treatment of skin wound with a mixture of PRP and HCF exerts sustained release of several growth factors contained in PRP and promotes skin wound healing. The release of fibroblast growth factor 2, platelet-derived growth factor-BB, and vascular endothelial growth factor contained in PRP from HCF was sustained for a longer period than those from PRP, calcium-activated PRP (C-PRP), or a mixture of fibrin and PRP (F-PRP). Treatment of full-thickness skin wounds in mice with HCF-PRP resulted in much faster wound closure as well as dermal and epidermal regeneration at day 12 compared to treatment with either C-PRP or F-PRP. Enhanced skin regeneration observed in HCF-PRP group may have been at least partially due to enhanced angiogenesis in the wound beds. Therefore, this method could be useful for skin wound treatment.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Regeneration / Skin / Wound Healing / RNA, Messenger / Fibrin / Heparin / Blotting, Western / Fibroblast Growth Factor 2 / Immunoenzyme Techniques / Dermis Limits: Animals Language: English Journal: Experimental & Molecular Medicine Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Regeneration / Skin / Wound Healing / RNA, Messenger / Fibrin / Heparin / Blotting, Western / Fibroblast Growth Factor 2 / Immunoenzyme Techniques / Dermis Limits: Animals Language: English Journal: Experimental & Molecular Medicine Year: 2011 Type: Article