Clinical Implication of TSH Receptor Antibody Measurement
International Journal of Thyroidology
;
: 15-18, 2016.
Article
in Korean
| WPRIM
| ID: wpr-122232
ABSTRACT
Autoantibodies directed against the thyrotropin receptor have been well known to be an important pathogenesis of Graves' disease. However, the diagnosis and management of Graves' disease are still mainly dependent on thyroid function itself and clinical manifestation of thyrotoxic patients. That is mainly due to the low sensitivity of early generation of thyrotropin receptor assay methods. The development of sensitive thyrotropin receptor measuring tools through third generation immunometric assay made the diagnosis of Graves' disease with mild hyperthyroidism accurate and convenient for patients. Bioassay to detect thyroid stimulating immunoglobulin is also commercially available nowadays, which theoretically discriminate thyroid stimulating antibodies from thyrotropin receptor-blocking antibodies. Although the use of these serologic markers plays an informative role in accurately diagnosing Graves' disease and predicting the prognosis of disease, consideration of the heterogeneous nature of autoimmunity of Graves' disease and the limitation of indirect antibody assay is also required for proper management of Graves' disease patients. In this review, the clinical usefulness of thyrotropin receptor antibody in various clinical situations of Graves' disease was overviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Autoantibodies
/
Thyroid Gland
/
Biological Assay
/
Receptors, Thyrotropin
/
Thyrotropin
/
Autoimmunity
/
Graves Disease
/
Immunoglobulins, Thyroid-Stimulating
/
Diagnosis
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
International Journal of Thyroidology
Year:
2016
Type:
Article
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