A Case of Severe Chronic Active Epstein-Barr Virus Infection with T-cell lymphoproliferative Disorder
The Korean Journal of Internal Medicine
;
: 124-127, 2004.
Article
in English
| WPRIM
| ID: wpr-122272
ABSTRACT
Chronic infection with Epstein-Barr virus (EBV) without previous immunodeficiency or immuno-suppressive therapy is relatively rare. Severe chronic active EBV (SCAEBV) infection was reported for the first time in 1984 as 'chronic mononucleosis syndrome', and diagnostic criteria were proposed. It is characterized by clinical features including fever, severe hepatosplenomegaly, lymphadenopathy, hematologic features such as anemia and thrombocytopenia, and elevated antibody titers to EBV. We experienced a 21-year-old woman who initially presented with fever and chronic fatigue; however, no definite diagnosis could be made at the time of admission. Three months after the initial admission, there was evidence of only splenomegaly and the patient had persistent, multiple, paraaortic lymphadenopathies in abdominal CT. Diagnostic splenectomy was performed, and SCAEBV infection with T-cell lymphoproliferative disorder was ultimately diagnosed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Splenectomy
/
Severity of Illness Index
/
T-Lymphocytes
/
Tomography, X-Ray Computed
/
Chronic Disease
/
Epstein-Barr Virus Infections
/
Diagnosis, Differential
/
Lymphoproliferative Disorders
Type of study:
Diagnostic study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2004
Type:
Article
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