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Herpes Simplex Esophagitis Following Cadaveric Renal Transplantation / 대한이식학회지
The Journal of the Korean Society for Transplantation ; : 177-181, 1999.
Article in Korean | WPRIM | ID: wpr-122395
ABSTRACT
Herpes simplex esophagitis usually occurs in immunocompromised or severely debilitated patients. Odynophagia and dysphagia are major symptoms and the prognosis of immunocompromised patients is variable. We present the case of a cadeveric donor renal transplantation recipient who developed herpes simplex esophagitis shortly after anti-rejection therapy. A 43-years-old female had cadaveric renal transplantation and following treatment with cyclosporine, prednisolone, mycophenolate mofetile. Twelve months later, renal insufficieny and proteinuria were developed. Allograft kidney biopsy showed some evidence of acute rejection. She was treated with 3 successive days of intravenous methylpredinisolone (500 mg/d) therapy and continued tapering of steroids. Two weeks later, she had oral cavity ulceration, odynophagia, dysphagia, epigastric pain, and nausea. Esophagoscopy reveals multiple confluent ulceration in the whole part of esophagus and biopsies showed the epithelial cell were enlarged with prominent nuclei. Immunohistochemically, the epithelial cell were positive with a monoclonal antibody to herpes simplex virus type 1. Treatment was started on intravenous ayclovir and changed to oral agent for 10 days. After treatment, her symptoms and repeat endoscopic findings were improved.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Proteinuria / Steroids / Tissue Donors / Ulcer / Biopsy / Cadaver / Prednisolone / Deglutition Disorders / Esophagoscopy Type of study: Prognostic study Limits: Female / Humans Language: Korean Journal: The Journal of the Korean Society for Transplantation Year: 1999 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Proteinuria / Steroids / Tissue Donors / Ulcer / Biopsy / Cadaver / Prednisolone / Deglutition Disorders / Esophagoscopy Type of study: Prognostic study Limits: Female / Humans Language: Korean Journal: The Journal of the Korean Society for Transplantation Year: 1999 Type: Article