Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells
Experimental & Molecular Medicine
;
: 805-810, 2010.
Article
in English
| WPRIM
| ID: wpr-122578
ABSTRACT
Tumor necrosis factor receptor-related 2 (TR2, HVEM or TNFRSF-14) plays an important role in immune responses, however, the mechanisms regulating its expression are unclear. To understand the control of TR2 gene expression, we studied the upstream region of the gene. Gel supershift assays revealed inducible binding of nuclear factor of activated T cells (NFAT) to a putative NFAT site within the TR2 promoter. Furthermore, cotransfection of a dominant negative NFAT construct, or siRNA for NFAT, resulted in increased expression of a TR2 reporter gene. Our findings demonstrate that NFAT negatively regulates TR2 expression in activated T cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Molecular Sequence Data
/
Base Sequence
/
T-Lymphocytes
/
CD4-Positive T-Lymphocytes
/
Down-Regulation
/
Cells, Cultured
/
NFATC Transcription Factors
/
Receptors, Tumor Necrosis Factor, Member 14
/
Mice, Inbred C57BL
Limits:
Animals
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2010
Type:
Article
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