Role of CD4(+)CD25(high+)FOXP3(+) Regulatory T Cells in Psoriasis
Annals of Dermatology
;
: 397-403, 2010.
Article
in English
| WPRIM
| ID: wpr-122632
ABSTRACT
BACKGROUND:
CD4(+)CD25(high+)regulatory T cells (Tregs) are considered to be of vital importance for maintaining immunologic self-tolerance and preventing autoimmune diseases. These cells have been found to be deficient in skin lesions and in the peripheral blood of patients with psoriasis.OBJECTIVE:
To investigate the role of Tregs in the pathogenesis of psoriasis and to evaluate the changes in Tregs in relation to the severity and the clinical course of psoriasis.METHODS:
Immunohistochemistry (CD3, 4, 8, 79 and FOXP3) was performed in 22 psoriatic patients compared to 5 normal controls. Flow cytometry (CD3, 4, 8, 25 and FOXP3) was performed in 18 psoriatic patients and 8 normal volunteers and reverse transcriptase polymerase chain reaction (foxp3 mRNA) was performed in 8 psoriasis patients.RESULTS:
An increase in the FOXP3(+) cell fraction was detected in the lesional psoriatic skin irrespective of the severity of psoriasis as compared with the normal skin. However, a decrease in FOXP3(+) cells was observed in the samples obtained from psoriasis of 'acute course'. FOXP3(+) Treg populations in the blood of the 'acute course' psoriasis was not different compared to that of 'chronic course' psoriasis and normal controls.CONCLUSION:
The deficiency of FOXP3(+) Tregs in the lesional psoriatic skin might be responsible for the exacerbation of psoriasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psoriasis
/
Skin
/
Autoimmune Diseases
/
Immunohistochemistry
/
T-Lymphocytes
/
T-Lymphocytes, Regulatory
/
Reverse Transcriptase Polymerase Chain Reaction
/
Flow Cytometry
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2010
Type:
Article
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