Suppression of Aurora-A oncogenic potential by c-Myc downregulation
Experimental & Molecular Medicine
;
: 759-767, 2010.
Article
in English
| WPRIM
| ID: wpr-122640
ABSTRACT
The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together, our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cell Line, Transformed
/
Down-Regulation
/
Gene Expression Regulation, Neoplastic
/
Transcriptional Activation
/
Cell Transformation, Neoplastic
/
Proto-Oncogene Proteins c-myc
/
Cisplatin
/
Protein Serine-Threonine Kinases
/
Transgenes
/
RNA, Small Interfering
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2010
Type:
Article
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