Outcome and Risk Factor of Early Recurrence of Hepatocellular Carcinoma after Liver Transplantation and Effect of Pre-transplant Transarterial chemoembolization on Post-transplant Outcome
Journal of the Korean Surgical Society
;
: 379-386, 2007.
Article
in Korean
| WPRIM
| ID: wpr-122655
ABSTRACT
PURPOSE:
The aims of this study were to find the risk factor and outcomes of patients with an early recurrence (ER) of a hepatocellular carcinoma (HCC) after liver transplantation (LT) and the actual impact of transarterial chemoembolization (TACE) before LT for a HCC on patient survival and HCC recurrence.METHODS:
Ninety-eight cases of adult LT, performed between September 1995 and January 2006, were evaluated. The risk factors and prognosis of patient with a HCC after transplantation for an ER, defined as a recurrence within 6 months of transplantation, and the effects of Pre-LT TACE on the disease-free and overall survival rates, as well as the patterns of recurrence after LT, were studied.RESULTS:
A total of 18 patients (18.4%) experienced a HCC recurrence after LT; 10 and 8 patients had early and late recurrences, respectively. From a univariate analysis, the serum alpha-fetoprotein (P=0.003), tumor size (P=0.003), serosa invasion (P=0.000), tumor grade (P=0.011) and vascular invasion (P=0.014) were statistically significant risk factors for an ER. From a multivariate analysis, the presence of serosa invasion of a HCC was the only independent risk factor for an ER (P=0.009; OR=9.407 95% CI, 1.764~50.164). There was no difference in the disease free sur-vival and overall survival rates between the TACE and without TACE groups, but the extrahepatic recurrence rate was higher in the TACE than without TACE group.CONCLUSION:
Serosa invasion by a HCC is independently associated with an ER of HCC after LT. Pre-LT TACE does not influence the disease-free and overall survivals after LT for a HCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
Serous Membrane
/
Alpha-Fetoproteins
/
Multivariate Analysis
/
Survival Rate
/
Risk Factors
/
Liver Transplantation
/
Carcinoma, Hepatocellular
/
Liver
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Journal of the Korean Surgical Society
Year:
2007
Type:
Article
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