Impact of hydroxyethyl starch 70/0.5 on acute kidney injury after gastroenterological surgery / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 460-467, 2016.
Article
in English
| WPRIM
| ID: wpr-123012
ABSTRACT
BACKGROUND:
Previous studies reported a higher mortality risk and a greater need for renal replacement therapy in patients administered hydroxyethyl starch (HES) rather than other fluid resuscitation preparations. In this study, we investigated the association between 6% HES 70/0.5 use and postoperative acute kidney injury (AKI) in gastroenterological surgery patients.METHODS:
We conducted retrospective full-cohort and propensity-score-based analyses of patients who underwent gastroenterological surgery between June 2011 and August 2013 in a Japanese university hospital. The study sample comprised 66 AKI and 2,152 non-AKI patients in the full-cohort analysis and 35 AKI and 1,269 non-AKI patients in the propensity-score-based analysis. Propensity scores were calculated using an ordered logistic regression model in which the dependent variable comprised three groups based on HES infusion volumes (0, 1–999, and ≥ 1,000 ml). The association between HES groups and postoperative AKI incidence was analyzed using multiple logistic regression models. Other candidate independent variables included patient characteristics and intraoperative measures.RESULTS:
In the full-cohort analysis, 40 (60.6%) AKI patients were diagnosed as "risk", 15 (22.7%) as "injury," and 11 (16.7%) as "failure". In the propensity-score-based analysis, the corresponding values were 22 (62.9%), 8 (22.9%), and 5 (14.3%). There was no significant association between total infused HES and postoperative AKI incidence in either the full-cohort or the propensity-score-based analysis (P = 0.168 and P = 0.42, respectively).CONCLUSIONS:
AKI incidence was not associated with clinical 6% HES 70/0.5 administration in gastroenterological surgery patients treated at a single center.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Resuscitation
/
Starch
/
Logistic Models
/
Incidence
/
Retrospective Studies
/
Mortality
/
Renal Replacement Therapy
/
Asian People
/
Propensity Score
/
Acute Kidney Injury
Type of study:
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2016
Type:
Article
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