Safety of intravitreally injected ciprofloxacin in phakic rabbit eyes
Korean Journal of Ophthalmology
;
: 12-18, 1995.
Article
in English
| WPRIM
| ID: wpr-123066
ABSTRACT
This study was designed to determine the maximal safe drug concentration of intravitreal ciprofloxacin in phakic rabbit eyes. Twenty-two eyes of New Zealand pigmented rabbits received midvitreal ciprofloxacin of 100, 200, 400, 600 or 800 microgram in BSS Plus, or BSS Plus only. Retinal toxicity was dose-dependent as determined with electroretinography, light microscopy, and transmission electron microscopy. At a dose of greater than 400 microgram, disorganization of the outer segments was a main pathological finding in transmission electron microscopy. We evaluated retinal function by measuring the electroretinograms for a graded series of flash intensities and by fitting electroretinogram b-wave amplitudes to the Naka-Rushton equation. At a dose of greater than 600 microgram, Rmax was significantly decreased and log K was significantly increased. N-value tended to decrease. A decrease of b-wave amplitudes caused by retinal toxicity could be detected very sensitively with lower luminance stimuli. Determination of retinal toxicity with lower luminance electroretinography revealed a significant decrease of b-wave amplitudes at a dose of greater than 400 microgram. We concluded that a safe dose of intravitreal ciprofloxacin in phakic rabbit eyes was 200 microgram in phakic eyes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Photic Stimulation
/
Retina
/
Rod Cell Outer Segment
/
Vitreous Body
/
Ciprofloxacin
/
Dose-Response Relationship, Drug
/
Electroretinography
/
Injections
/
Lens, Crystalline
Limits:
Animals
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
1995
Type:
Article
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