A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication
Journal of Korean Medical Science
;
: 750-752, 2004.
Article
in English
| WPRIM
| ID: wpr-123117
ABSTRACT
We present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT). Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype CYP2D6*5/*10B. This case suggests the clinical usefulness of pharmacogenetic testing in individualized dosage adjustments of NT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cytochrome P-450 CYP2D6
/
Depression
/
Genotype
/
Antidepressive Agents, Tricyclic
/
Nortriptyline
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2004
Type:
Article
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