Identifying Genetic Susceptibility to Sensitization to Cephalosporins in Health Care Workers
Journal of Korean Medical Science
;
: 1292-1299, 2012.
Article
in English
| WPRIM
| ID: wpr-123165
ABSTRACT
Exposure to cephalosporins could cause occupational allergic diseases in health care workers (HCWs). We evaluated the prevalence of serum specific IgE and IgG antibodies to cephalosporin-human serum albumin (HSA) conjugate and to identify potential genetic risk factors associated with sensitization to cephalosporins in exposed HCWs. The study population consisted of 153 HCWs who had been exposed to antibiotics in a single university hospital and 86 unexposed healthy controls. A questionnaire survey of work-related symptoms (WRS) was administered. A skin-prick test (SPT) was performed, and serum-specific IgE and IgG antibodies to 3 commonly prescribed cephalosporins were measured by ELISA. Four single-nucleotide polymorphisms of the candidate genes related to IgE sensitization were genotyped. The prevalence of WRS to cephalosporins was 2.6%. The prevalence rates of serum-specific IgE and IgG antibodies to cephalosporins were 20.3% and 14.7%, respectively. The FcepsilonR1beta-109T > C polymorphism was significantly associated with IgE sensitization to cephalosporins in HCWs (P = 0.036, OR = 3.553; CI, 1.324-9.532). The in vitro functional assay demonstrated that the T allele of FcepsilonR1beta-109T had greater promoter activity than did the C allele (P C polymorphism may be a potential genetic risk factor for increased IgE sensitization to cephalosporins.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin E
/
Immunoglobulin G
/
Enzyme-Linked Immunosorbent Assay
/
Skin Tests
/
Odds Ratio
/
Cephalosporins
/
Surveys and Questionnaires
/
Occupational Exposure
/
Health Personnel
/
Receptors, IgE
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2012
Type:
Article
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