A Genome-wide Association Study of Copy Number Variation in Hematological Parameters in the Korean Population
Genomics & Informatics
;
: 122-130, 2010.
Article
in English
| WPRIM
| ID: wpr-12319
ABSTRACT
Abnormal hematological values are associated with various disorders including cancer and cardiovascular, metabolic, infectious, and immune diseases. We report the copy number variations (CNVs) in clinically relevant hematological parameters, including hemoglobin level, red and white blood cell counts, platelet counts, and red blood cell (RBC) volume. We describe CNVs in several loci associated with these hematological parameters in 8,842 samples from Korean population-based studies. The data that we evaluated included four RBC parameters, one platelet parameter, and one associated with total white blood cell (WBC) count, exceeding the genome-wide significance. We show that CNVs in hematological parameters are associated with some loci, different from previously associated loci reported in single nucleotide polymorphism (SNP) association studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Blood Cell Count
/
Blood Platelets
/
Hemoglobins
/
Coat Protein Complex I
/
Polymorphism, Single Nucleotide
/
Erythrocytes
/
Genome-Wide Association Study
/
Immune System Diseases
/
Leukocyte Count
Language:
English
Journal:
Genomics & Informatics
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS