The Expression of Programmed Death-1 in Circulating CD4+ and CD8+ T Cells during Hepatitis B Virus Infection Progression and Its Correlation with Clinical Baseline Characteristics
Gut and Liver
; : 186-195, 2014.
Article
in En
| WPRIM
| ID: wpr-123192
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS: Programmed death-1 (PD-1) expression was investigated in CD4+ and CD8+ T cells from hepatitis B virus (HBV)-infected patients at the chronic hepatitis B (CHB) infection, liver cirrhosis (LC), and hepatocellular carcinoma (HCC) stages. METHODS: PD-1 expression in circulating CD4+ and CD8+ T cells was detected by flow cytometry. The correlations between PD-1 expression and HBV viral load, alanine aminotransaminase (ALT) levels and aspartate aminotransferase (AST) levels were analyzed using GraphPad Prism 5.0. RESULTS: PD-1 expression in CD4+ and CD8+ T cells was significantly increased in both the CHB group and advanced-stage group (LC plus HCC). In the CHB group, PD-1 expression in both CD4+ and CD8+ T cells was positively correlated with the HBV viral load, ALT, and AST levels. However, in the LC plus HCC group, significant correlations between PD-1 expression and the clinical parameters were nearly absent. CONCLUSIONS: PD-1 expression in peripheral CD4+ and CD8+ T cells is dynamic, changes with HBV infection progression, and is related to HBV viral load and liver function, especially in CHB. PD-1 expression could be utilized as a potential clinical indicator to determine the extent of virus replication and liver injury.
Key words
Full text:
1
Index:
WPRIM
Main subject:
CD4-Positive T-Lymphocytes
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Carcinoma, Hepatocellular
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Disease Progression
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CD8-Positive T-Lymphocytes
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Viral Load
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Hepatitis B, Chronic
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Programmed Cell Death 1 Receptor
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Liver Cirrhosis
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Liver Neoplasms
Limits:
Adult
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Female
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Humans
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Male
Language:
En
Journal:
Gut and Liver
Year:
2014
Type:
Article