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Symptom Characteristics and Psychosomatic Profiles in Different Spectrum of Gastroesophageal Reflux Disease
Gut and Liver ; : 165-169, 2014.
Article in English | WPRIM | ID: wpr-123195
ABSTRACT
BACKGROUND/

AIMS:

Gastroesophageal reflux disease (GERD) is diagnosed based on symptoms of heartburn and regurgitation but is a heterogeneous condition which can be subclassified according to endoscopy and esophageal reflux monitoring. The aim of this study was to identify differences in demographic characteristics and reflux symptom patterns among patients with various spectrum of GERD.

METHODS:

Patients having weekly heartburn or acid regurgitation were classified into four pathophysiological subgroups according to endoscopy and pH monitoring reflux esophagitis (RE), endoscopy-negative reflux disease with pathological reflux (PR+), hypersensitive esophagus (HE), and normal acid exposure with negative symptom association (pH-).

RESULTS:

A total of 195 patients were enrolled. The numbers of patients in the subgroups were RE, 39.0%; PR+, 20.0%; HE, 10.3%; and pH-, 30.8%. Grossly, reflux symptom patterns and relieving/exacerbating factors did not differ between subgroups. Prevalence of extraesophageal syndrome was higher in patients with PR+ than in other groups. Overlapping functional dyspepsia was common in all groups. The SCL-90-R depression score was higher in PR+ patients than in RE patients (p<0.05).

CONCLUSIONS:

Demographic characteristics and reflux symptom patterns cannot differentiate pH- group from GERD subtypes. Esophageal pH monitoring could be considered for the initial evaluation of GERD in the tertiary referral setting.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Psychophysiologic Disorders / Esophagitis, Peptic / Gastroesophageal Reflux / Surveys and Questionnaires / Retrospective Studies / Irritable Bowel Syndrome / Depressive Disorder / Esophageal pH Monitoring Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Psychophysiologic Disorders / Esophagitis, Peptic / Gastroesophageal Reflux / Surveys and Questionnaires / Retrospective Studies / Irritable Bowel Syndrome / Depressive Disorder / Esophageal pH Monitoring Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Gut and Liver Year: 2014 Type: Article