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Palonosetron versus granisetron in combination with aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with gynecologic cancer / 부인종양
Journal of Gynecologic Oncology ; : 311-319, 2015.
Article in English | WPRIM | ID: wpr-123435
ABSTRACT

OBJECTIVE:

There is no research regarding the appropriate antiemetic agents for female patients, especially those receiving moderately emetogenic chemotherapy (MEC). We evaluated the antiemetic efficacy of a combination of 5-HT3 receptor with/without aprepitant in patients with gynecological cancer treated with the TC (paclitaxel and carboplatin) regimen of MEC.

METHODS:

We enrolled 38 patients diagnosed with gynecologic cancer and scheduled to receive the TC regimen. The patients were randomly assigned to receive a 5-HT3 receptor antagonist, either palonosetron in the first cycle followed by granisetron in the second cycle or vice versa. In the third cycle, all patients received a combination of the 5-HT3 receptor and dexamethasone with/without aprepitant.

RESULTS:

When three drugs were administered, palonosetron consistently produced an equivalent complete response (CR) rate to granisetron in the acute phase (89.5% vs. 86.8%, p=0.87) and delayed phase (60.5% vs. 65.8%, p=0.79). With regard to the change in dietary intake, palonosetron exhibited similar efficacy to granisetron in the acute phase (92.1% vs. 89.4%, p=0.19) and delayed phase (65.7% vs. 68.4%, p=0.14). However, in the delayed phase, the addition of aprepitant therapy with a 5-HT3 receptor antagonist and dexamethasone produced a higher CR rate than a 5-HT3 receptor antagonist with dexamethasone (93.3% vs. 47.8%, p<0.001) and allowed the patients to maintain a higher level of dietary intake (93.3% vs. 56.5%, p<0.001).

CONCLUSION:

The addition of aprepitant therapy was more effective than the control therapy of a 5-HT3 receptor antagonist, and dexamethasone in gynecological cancer patients treated with the TC regimen.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Quinuclidines / Vomiting / Drug Administration Schedule / Antineoplastic Combined Chemotherapy Protocols / Morpholines / Carboplatin / Paclitaxel / Granisetron / Cross-Over Studies / Diet Type of study: Controlled clinical trial Limits: Adult / Aged / Female / Humans Language: English Journal: Journal of Gynecologic Oncology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quinuclidines / Vomiting / Drug Administration Schedule / Antineoplastic Combined Chemotherapy Protocols / Morpholines / Carboplatin / Paclitaxel / Granisetron / Cross-Over Studies / Diet Type of study: Controlled clinical trial Limits: Adult / Aged / Female / Humans Language: English Journal: Journal of Gynecologic Oncology Year: 2015 Type: Article