Biological roles of insulin-like growth factor binding proteins (IGFBPs)
Experimental & Molecular Medicine
;
: 85-96, 1997.
Article
in English
| WPRIM
| ID: wpr-123624
ABSTRACT
The insulin-like growth factor binding protein (IGFBP) family is a critical component of the insulin-like growth factor (IGF) system which regulate the biological actions of the IGFs and may also be capable of IGF-independent actions. To date, seven distinct IGFBPs have been described. Among these IGFBPs, IGFBPs-1-6 bind IGFs with high affinity, while only IGFBP-7 binds with low affinity. Recently, we have demonstrated that connective tissue growth factor (CTGF) also binds IGFs with low affinity, suggesting that a family of low-affinity IGFBPs, distinct from the high-affinity members, may exist, and together these constitute an IGFBP superfamily. IGFBPs have various biological roles. IGFBPs act not only as a carrier proteins, but also as a modulators of IGF actions by involving in IGF ligand-receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. In addition, some IGFBPs (IGFBPs-1, -3, and -5) appears to have intrinsic activity independent of IGFs. This review will focus on recent studies on the biological roles of IGFBPs in IGF-dependent and IGF-independent modes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Somatomedins
/
Biological Availability
/
Carrier Proteins
/
Insulin-Like Growth Factor Binding Proteins
/
Connective Tissue Growth Factor
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
1997
Type:
Article
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