Effect of isoflurane versus propofol-remifentanil anesthesia on neuromuscular blockade and hemodynamic responses by cisatracurium bolus injection / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 297-301, 2011.
Article
in English
| WPRIM
| ID: wpr-123655
ABSTRACT
BACKGROUND:
Inhalational anesthetics potentiate nondepolarizing muscle relaxants. Cisatracurium is a recently introduced neuromuscular blocker in Korea. We studied the effect of inhalational anesthesia and total intravenous anesthesia (TIVA) on neuromuscular blockades and hemodynamic responses by cisatracurium bolus injection.METHODS:
Forty patients undergoing elective surgery were randomly divided into isoflurane and propofol-remifentanil groups. A bolus dose of cisatracurium of 0.15 mg/kg (3 x ED95) was administered after induction and the onset time and clinical duration of action were recorded. The nueromuscular blockade was monitored using train-of-four (TOF) stimulation. Hemodynamic parameters were also recorded.RESULTS:
Onset time was 194.0 +/- 39.1 sec in the isoflurane group and 226.5 +/- 62.2 sec in the propofol-remifentanil group. Clinical duration of action was 49.2 +/- 9.0 min in the isoflurane group and 43.0 +/- 9.2 min in the propofol-remifentanil group. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) immediately before intubation decreased in the propofol-remifentanil group. Heart rate (HR), SBP and DBP 1 and 3 min after tracheal intubation increased in the isoflurane group.CONCLUSIONS:
Onset time was similar between isoflurane and propofol-remifentanil anesthesia. Clinical duration of action was significantly longer in isoflurane anesthesia. SBP and DBP immediately before intubation and HR, SBP and DBP 1 and 3 min after tracheal intubation were significantly different between the two groups.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperidines
/
Blood Pressure
/
Atracurium
/
Propofol
/
Neuromuscular Blockade
/
Heart Rate
/
Hemodynamics
/
Intubation
/
Isoflurane
/
Anesthesia
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2011
Type:
Article
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