Clinicopathologic Characteristics of Left-Sided Colon Cancers with High Microsatellite Instability
Korean Journal of Pathology
;
: 428-434, 2009.
Article
in English
| WPRIM
| ID: wpr-123700
ABSTRACT
BACKGROUND:
High microsatellite instability (MSI-H) colorectal carcinomas (CRCs) with numerous mutations in the microsatellite sequence are characterized by a right-sided preponderance, frequent peritumoral and intratumoral lymphocytic infiltration, and frequent mucin production. However, no study has correlated anatomic site and type of genetic changes with clinicopathologic changes.METHODS:
We analyzed the histopathologic features of 135 MSI-H CRCs and compared them to 140 microsatellite stable (MSS) CRCs. Histopathologic changes in MSI-H were further analyzed according to anatomic sites and genetic changes.RESULTS:
MSI-H CRCs showed previously reported clinicopathologic findings; a right-sided preponderance, an increased number of mucinous carcinomas, and peritumoral lymphoid reactions (p<0.001 for each variable). Increased serum CEA levels showed an MSS CRC preponderance (p=0.013). We further analyzed the histologic differences between right- and left-sided MSI-H tumors. We found that MSI-H CRCs on both sides had similar clinicopathologic findings, except for higher tumor stage (p=0.048) and less frequent abnormal CEA levels in left-sided MSI-H tumors (p=0.027). We found that not all clinicopathologic features were different between hereditary nonpolyposis colorectal cancers (HNPCCs) and sporadic MSI-H CRCs.CONCLUSIONS:
These findings indicate that MSI-H CRCs of the left colon have similar clinicopathologic characteristics as right-sided MSI-H CRCs. We did not find any significant clinicopathological difference between HNPCCs and sporadic MSI-H CRCs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Zinc Oxide
/
Calcium Hydroxide
/
Colorectal Neoplasms
/
Colorectal Neoplasms, Hereditary Nonpolyposis
/
Colon
/
Colonic Neoplasms
/
Adenocarcinoma, Mucinous
/
Microsatellite Repeats
/
Microsatellite Instability
/
Mucins
Language:
English
Journal:
Korean Journal of Pathology
Year:
2009
Type:
Article
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