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Clinical Usefulness of Combined Cardiac Marker Testing with a Point-of-Care Device at the Emergency Department
Journal of Laboratory Medicine and Quality Assurance ; : 83-89, 2017.
Article in English | WPRIM | ID: wpr-12376
ABSTRACT

BACKGROUND:

B-type natriuretic peptide (BNP) levels are elevated in various conditions unrelated to heart failure, such as acute coronary syndrome, and cardiac troponin (cTn) levels may also be elevated in several non-ischemic conditions. This study aimed to evaluate the clinical usefulness of combined cardiac marker testing (BNP and cTnI) with point-of-care devices in patients who presented to the emergency department (ED).

METHODS:

Two thousand six hundred and seventy-four consecutive patients who visited the ED from March to August 2013 were included in this study. Cardiac marker testing was performed using the Triage Cardio3 panel (Alere, USA). Electronic medical records were collected on August 2014.

RESULTS:

We found that 22.2% patients had elevated BNP and/or cTnI (12.8% with only elevated BNP, 4.4% with only elevated cTnI, and 5.0% with both elevations). Patients with elevations in both marker levels showed significantly higher admission rate (78.5% vs. 62.7%, P=0.006) and longer length of hospital stay (11 vs. 6 days, P=0.001) than those with only elevated cTnI. Patients with elevations in both marker levels also showed higher admission rate (78.5% vs. 67.3%, P=0.016) and higher BNP levels (430 vs. 194 pg/mL, P<0.001) than those with only elevated BNP.

CONCLUSIONS:

Concurrent elevation of BNP and cTnI may be associated with inferior clinical outcome and combined testing of cTnI and BNP levels with high sensitivity would provide important information for assisting management decisions at the ED.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Troponin / Triage / Point-of-Care Systems / Troponin I / Natriuretic Peptide, Brain / Emergencies / Emergency Service, Hospital / Acute Coronary Syndrome / Electronic Health Records / Heart Failure Type of study: Prognostic study Limits: Humans Language: English Journal: Journal of Laboratory Medicine and Quality Assurance Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Troponin / Triage / Point-of-Care Systems / Troponin I / Natriuretic Peptide, Brain / Emergencies / Emergency Service, Hospital / Acute Coronary Syndrome / Electronic Health Records / Heart Failure Type of study: Prognostic study Limits: Humans Language: English Journal: Journal of Laboratory Medicine and Quality Assurance Year: 2017 Type: Article