Analysis of C(-634)G polymorphism in the promotor region of the vascular endothelial growth factor gene in Korean women with endometriosis / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 119-125, 2005.
Article
in Korean
| WPRIM
| ID: wpr-123815
ABSTRACT
OBJECTIVE:
This study was designed to investigate the association between C(-634)G polymorphism in the promotor region of vascualr endothelial growth factor (VEGF) and endometriosis.METHODS:
The genomic DNA was extracted from 100 patients with surgically confirmed endometriosis and 100 control group from July 2003 to June 2004. Following extraction of genomic DNA, genotyping of C(-634)G polymorphism of VEGF gene was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).RESULTS:
There was no significant difference in the frequency of CC genotype between the patients with endometriosis (21%) and the control group (19%). No significant difference in the frequency of allele of -634C was noted between the two groups (43.5% vs 44%), either.CONCLUSION:
The C(-634)G polymorphism in the promotor region of VEGF gene is not associated with susceptibility to endometriosis in Korean women.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Restriction Fragment Length
/
DNA
/
Polymerase Chain Reaction
/
Endothelial Growth Factors
/
Promoter Regions, Genetic
/
Vascular Endothelial Growth Factor A
/
Endometriosis
/
Alleles
/
Genotype
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2005
Type:
Article
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