Influences of the Intrapulmonary R-->L Shunt on PaO2 and PaCO2 after Instillation of Exogenous Pulmonary Surfactant to Premature Neonates with Respiratory Distress Syndrome
Journal of the Korean Pediatric Society
;
: 1508-1519, 1997.
Article
in Korean
| WPRIM
| ID: wpr-123847
ABSTRACT
PURPOSE:
We are inclined to analyze the relationship between the intrapulmonary right-to-left shunt and the PaO2/PaCO2 after endotracheal single-dose surfactant instillation to premature neonates with respiratory distress syndrome within 6 hours after birth.METHODS:
From Jan. 1993 to Jun. 1995, we have conducted a clinical trial of surfactant replacement therapy to the premature neonates with respiratory distress syndrome at the neonatal intensive care unit of InHa University Hospital. The surfactant group (n=17) was given Surfactant-TA and mechanical ventilator care, but the control group (n=22) was treated with only mechanical ventilator. We analyzed umbilical arterial blood gases and estimated respiratoy indexes before and after treatment.RESULTS:
1) The QSP/QT decreased initially in the surfactant group, but significantly increased 24 hours after treatment in the control group (40.6+/-4.7%, P0.5) resulted in a decrease in PaO2 and also a significant relationship was found between the QSP/QT and the PaO2. However, there was no significant relationship between the QSP/QT and the PaCO2.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pulmonary Surfactants
/
Capillaries
/
Ventilators, Mechanical
/
Intensive Care, Neonatal
/
Hypocapnia
/
Parturition
/
Gases
Type of study:
Controlled clinical trial
Limits:
Humans
/
Infant, Newborn
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
1997
Type:
Article
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