The Effect of Low-dose Ketamine on Post-caesarean Delivery Analgesia after Spinal Anesthesia
The Korean Journal of Pain
;
: 270-276, 2013.
Article
in English
| WPRIM
| ID: wpr-12385
ABSTRACT
BACKGROUND:
Ketamine, an N-methyl-D-aspartate receptor antagonist, might play a role in postoperative analgesia, but its effect on postoperative pain after caesarean section varies with study design. We investigated whether the preemptive administration of low-dose intravenous ketamine decreases postoperative opioid requirement and postoperative pain in parturients receiving intravenous fentanyl with patient-controlled analgesia (PCA) following caesarean section.METHODS:
Spinal anesthesia was performed in 40 parturients scheduled for elective caesarean section. Patients in the ketamine group received a 0.5 mg/kg ketamine bolus intravenously followed by 0.25 mg/kg/h continuous infusion during the operation. The control group received the same volume of normal saline. Immediately after surgery, the patients were connected to a PCA device set to deliver 25-microg fentanyl as an intravenous bolus with a 15-min lockout interval and no continuous dose. Postoperative pain was assessed using the cumulative dose of fentanyl and visual analog scale (VAS) scores at 2, 6, 24, and 48 h postoperatively.RESULTS:
Significantly less fentanyl was used in the ketamine group 2 h after surgery (P = 0.033), but the difference was not significant at 6, 12, and 24 h postoperatively. No significant differences were observed between the VAS scores of the two groups at 2, 6, 12, and 24 h postoperatively.CONCLUSIONS:
Intraoperative low-dose ketamine did not have a preemptive analgesic effect and was not effective as an adjuvant to decrease opioid requirement or postoperative pain score in parturients receiving intravenous PCA with fentanyl after caesarean section.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain, Postoperative
/
Passive Cutaneous Anaphylaxis
/
Cesarean Section
/
Fentanyl
/
Analgesia, Patient-Controlled
/
N-Methylaspartate
/
Analgesia
/
Ketamine
/
Anesthesia, Spinal
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
The Korean Journal of Pain
Year:
2013
Type:
Article
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