The Effect of Cyanidin-3-O-beta-d-glucopyranoside on the Penile Erection and Corpus Cavernosum in a Rat Model of Diabetic Erectile Dysfunction / 대한남성과학회지
Korean Journal of Andrology
;
: 127-133, 2011.
Article
in English
| WPRIM
| ID: wpr-123885
ABSTRACT
PURPOSE:
The aim of this study was to evaluate Cyanidin-3-O-beta-d-glucopyranoside on improvement and protection for erectile function. MATERIALS ANDMETHODS:
Sprague-Dawley rats (12wks old) were divided into three groups (n=12 in each) normal control, diabetes (DM), and diabetes with Cyanidin-3-O-beta-d-glucopyranoside (C3G) concentration materials treatment (DM+C3G). DM and DM+C3G group received a single injection of streptozotocin (50 mg/kg), and 4 wk after induction of diabetes, DM+C3G group were treated with daily C3G (10 mg/kg) dissolved in water for 8 wk. After 12 wk of streptozotocin injections, rats in each group underwent intracavernosal pressure measurement (ICP) and then the corporal tissues were sampled.RESULTS:
DM group showed markedly lower erectile parameters than those in the control group, whereas rats in the DM+C3G group showed improved erectile function by minimizing corporal apoptosis.CONCLUSIONS:
The current study is the first to suggest that Cyanidin-3-O-beta-d-glucopyranoside may have a potency to improve and protect erectile function in a rat model of diabetic erectile dysfunction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penile Erection
/
Water
/
Rats, Sprague-Dawley
/
Streptozocin
/
Diabetes Mellitus
/
Erectile Dysfunction
Limits:
Animals
Language:
English
Journal:
Korean Journal of Andrology
Year:
2011
Type:
Article
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