Chronic Opisthorchis viverrini Infection and Associated Hepatobiliary Disease Is Associated with Iron Loaded M2-like Macrophages
The Korean Journal of Parasitology
;
: 695-699, 2014.
Article
in English
| WPRIM
| ID: wpr-124051
ABSTRACT
Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Opisthorchiasis
/
Opisthorchis
/
Immunohistochemistry
/
Mesocricetus
/
Gene Expression Profiling
/
Histocytochemistry
/
Iron
/
Liver Cirrhosis
/
Macrophages
Limits:
Animals
/
Humans
Language:
English
Journal:
The Korean Journal of Parasitology
Year:
2014
Type:
Article
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