Bradyarrhythmia Can Increase the Plasma Level of N-Terminal Pro-Brain Natriuretic Peptide
International Journal of Arrhythmia
;
: 112-117, 2016.
Article
in English
| WPRIM
| ID: wpr-124485
ABSTRACT
BACKGROUND AND OBJECTIVES:
Myocardial wall stretch is the main trigger for pro-brain natriuretic peptide (pro-BNP) secretion. The reduced heart rate associated with bradyarrhythmia increases stroke volume, resulting in increased wall tension. Therefore, we propose that bradyarrhythmia could increase plasma N-terminal pro-BNP (NT-pro-BNP) levels. SUBJECTS ANDMETHODS:
We enrolled 125 patients who received a temporary pacemaker because they had sinus node dysfunction (SND) or atrioventricular blocks (AVBs). Patients with renal dysfunction, hyperkalemia, reduced left ventricular systolic function (left ventricular ejection fraction [LVEF], 300 pg/mL. We evaluated history of hypertension, diabetes mellitus, and ischemic heart disease, plasma NT-pro-BNP levels, body mass index (BMI), LVEF, left atrial diameter (LAD), and escape rhythm rate.RESULTS:
The log plasma NT-pro-BNP level of the patients with AVBs was significantly increased compared to that of the patients with SND (3.17±0.55 vs. 2.93±0.64 pg/mL, respectively; p=0.03). The incidence of HF was 72.5% (106 patients; 44 male patients). Further, the incidence of HF was significantly higher among patients with AVBs than among patients with SND. The type of bradyarrhythmia was found to be the only predictor of HF after adjusting for age, history of hypertension, LAD, and LVEF. The LVEF, LAD, and ventricular rate were similar between the 2 groups.CONCLUSION:
As in the case of patients with tachyarrhythmia, bradyarrhythmia may increase plasma NT-pro-BNP levels, leading to HF. Therefore, the possibility of HF should be considered in patients with bradyarrhythmia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Arrhythmias, Cardiac
/
Atrial Fibrillation
/
Sick Sinus Syndrome
/
Stroke Volume
/
Tachycardia
/
United Nations
/
Bradycardia
/
Body Mass Index
/
Incidence
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
International Journal of Arrhythmia
Year:
2016
Type:
Article
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