Participation of IL-1β in temporomandibular nociception in rats with CFA-induced inflammation
International Journal of Oral Biology
;
: 125-131, 2016.
Article
in Korean
| WPRIM
| ID: wpr-124490
ABSTRACT
The aim of the present study was to develop an animal model for evaluation of temporomandibular (TMJ) nociception under TMJ inflammation. We also investigated the participation of IL-1β in inflammation-induced TMJ nociception. Experiments were carried out using male Sprague-Dawley rats. Intra-articular injection of 3% formalin was administered to evaluate hyperalgesia 3 days after CFA injection. Intra-articular injection of 3% formalin did not produce nociceptive behavior in normal rats. Although intra-articular injection of 3 doses of CFA produced TMJ inflammation, only 13 diluted CFA produced hyperalgesia when formalin was injected intra-articularly 3 days after CFA injection. Co-administration of IL-1 receptor inhibitor with formalin into the TMJ cavity 3 days after CFA injection was performed. Co-administration of IL-1 receptor inhibitor significantly inhibited formalin-induced hyperalgesia in rats with CFA-induced TMJ inflammation. These results suggested that intra-articular injection of formalin produced hyperalgesia under chronic TMJ inflammation. Moreover, IL-1β plays an important role in TMJ hyperalgesia under chronic inflammation and blockade of IL-1β is a potential therapeutic target for inflammatory TMJ pain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Temporomandibular Joint
/
Interleukin-1
/
Rats, Sprague-Dawley
/
Models, Animal
/
Nociception
/
Formaldehyde
/
Hyperalgesia
/
Inflammation
/
Injections, Intra-Articular
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
International Journal of Oral Biology
Year:
2016
Type:
Article
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