Durability of Sustained Virologic Response in Chronic Hepatitis C
Gut and Liver
;
: 458-461, 2013.
Article
in English
| WPRIM
| ID: wpr-124626
ABSTRACT
BACKGROUND/AIMS:
The aim of this study is to investigate the rate of sustained virologic response (SVR) in chronic hepatitis C patients receiving antiviral treatment.METHODS:
The files of patients with chronic hepatitis C treated with interferon+/-ribavirin between 1995 and 2009 were reviewed retrospectively. Six months after the end of treatment, patients with negative hepatitis C virus (HCV)-RNA (<50 IU/mL, as determined by the polymerase chain reaction method) were enrolled in the study.RESULTS:
The mean age of 196 patients (89 males) was 46.13+/-11.10 years (range, 17 to 73 years). In biopsies, the mean stage was 1.50+/-0.94; histological activity index was 7.18+/-2.43. In total, 139 patients received pegylated interferon (IFN)+ribavirin, 21 patients received classical IFN+ribavirin, and 36 patients received IFN alone. The HCV genotypes of 138 patients were checked 77.5% were genotype 1b, and 22.5% were other genotypes. After achievement of SVR, the median follow-up period was 33.5 months (range, 6 to 112 months), and in this period relapse was only detected in two patients (1.02%) at 18 and 48 months after treatment.CONCLUSIONS:
In total, 98.9% of patients with SVR in chronic hepatitis C demonstrated truly durable responses over the long-term follow-up period of 3 years; relapsed patients had intermittent or low-grade viremia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Achievement
/
Viremia
/
Biopsy
/
Polymerase Chain Reaction
/
Retrospective Studies
/
Follow-Up Studies
/
Interferons
/
Hepacivirus
/
Hepatitis C, Chronic
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2013
Type:
Article
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