No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation / 한국실험동물학회지
Laboratory Animal Research
;
: 90-93, 2014.
Article
in English
| WPRIM
| ID: wpr-124661
ABSTRACT
This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-respectively acquired from alpha-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 and 25 days-were xenografted into cynomolgus monkeys. The two PERV elements expressed in the xenografted GT-KO pig organs were not present in the blood cells of the recipient monkeys. In the present study, we deduced that PERVs are not transmitted during GT-KO pig to monkey xenotransplantation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Primates
/
Swine
/
Transplantation, Heterologous
/
Blood Cells
/
Haplorhini
/
Endogenous Retroviruses
/
Heterografts
/
Heart
/
Macaca fascicularis
Language:
English
Journal:
Laboratory Animal Research
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS