Assessment of the relationship between serum soluble Klotho and carotid intima-media thickness and left ventricular dysfunction in hemodialysis patients
Kidney Research and Clinical Practice
;
: 42-49, 2016.
Article
in English
| WPRIM
| ID: wpr-124839
ABSTRACT
BACKGROUND:
The aim of our study was to assess the relationship between soluble Klotho (s-Klotho) and carotid intima-media thickness (CIMT) and left ventricular (LV) dysfunction in hemodialysis (HD) patients.METHODS:
This is a cross-sectional study conducted on 88 patients with end-stage renal disease on regular HD. Serum levels of calcium, phosphorus, parathyroid hormone, and C-reactive protein were measured. The serum levels of s-Klotho and fibroblast growth factor-23 (FGF-23) were measured using an Enzyme linked immunosorbent assay (ELISA) kit. Echocardiography and measurement of CIMT were also conducted. The studied patients were divided according to the median s-Klotho level into 2 groups patients with low s-Klotho (Group I) and patients with high s-Klotho (Group II).RESULTS:
Mean value of s-Klotho was significantly low in HD patients compared to controls (P = 0.001), and mean value of FGF-23 was significantly high in HD patients compared to controls (P = 0.001). The mean values of parathyroid hormone, FGF-23, and phosphorus were significantly high in Group I compared to Group II, whereas the mean value of serum calcium was significantly low in Group I compared to Group II. The mean values of CIMT, LV mass (LVM), LVM index, and LV ejection fraction (LVEF) were high in Group I compared to Group II. Patients with low s-Klotho had significantly more coronary artery disease (CAD). In a regression analysis of s-Klotho with different markers of cardiovascular diseases, s-Klotho showed significant association with CIMT, LVEF, and CAD, but not with LVM and LVM index.CONCLUSION:
The present study showed that patients with a low s-Klotho were more often associated with increased CIMT, LV dysfunction, and CAD, and it seems that there was independent association between s-Klotho and CIMT, LVEF, and CAD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parathyroid Hormone
/
Phosphorus
/
Coronary Artery Disease
/
C-Reactive Protein
/
Enzyme-Linked Immunosorbent Assay
/
Echocardiography
/
Cardiovascular Diseases
/
Calcium
/
Cross-Sectional Studies
/
Renal Dialysis
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2016
Type:
Article
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