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Non-Spine Bone Metastasis as an Initial Manifestation of Cancer in Korea
Journal of Korean Medical Science ; : 357-362, 2014.
Article in English | WPRIM | ID: wpr-124856
ABSTRACT
Non-spine bone metastasis accounts for approximately 20% of all skeletal metastases, but little data have been published that focused on bone metastasis to the pelvis and extremities as an initial manifestation of cancer. We determined 1) clinicopathologic characteristics of patients who presented with non-spine bone metastasis of unknown primary malignancy, and 2) process by which the diagnosis of primary cancer was made. We retrospectively reviewed 84 patients with bone metastasis of unknown primary cancer site at the time of presentation. The study population consisted of 56 men and 28 women, with a mean age of 59.1 yr (17.5-85.6 yr). The average follow-up period was 20.8 months (1-120 mo). Primary cancer site was identified in 79 patients (94.0%), and was determined to be the lung (46.4%), kidney (13.1%), liver (9.5%), thyroid (8.3%), and prostate (4.8%). Five-year overall survival rate was 28.0%. Multiple bone metastases, distant organ metastasis, and multiple bone with organ metastases were the significant prognostic factors in univariate analysis. Multiple bone metastases remained significant after multivariate analysis (P = 0.008). Lung cancer is the most common site of primary cancer, and patients with multiple bone metastases have a poor prognosis, possibly due to disseminated cancer and a greater tumor burden.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Prostatic Neoplasms / Bone Neoplasms / Thyroid Neoplasms / Survival Rate / Retrospective Studies / Follow-Up Studies / Republic of Korea / Kidney Neoplasms / Liver Neoplasms Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Prostatic Neoplasms / Bone Neoplasms / Thyroid Neoplasms / Survival Rate / Retrospective Studies / Follow-Up Studies / Republic of Korea / Kidney Neoplasms / Liver Neoplasms Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2014 Type: Article