Novel Maintenance Therapy with Lamivudine in Patients with Chronic Active Viral Hepatitis B / 대한간학회지
The Korean Journal of Hepatology
;
: 301-310, 2000.
Article
in Korean
| WPRIM
| ID: wpr-125026
ABSTRACT
BACKGROUND/AIMS:
This study was conducted to determine the effect of novel long-term maintenance treatment with lamivudine by gradual lengthening of the medication interval in patients with chronic active viral hepatitis B.METHOD:
All patients were non-responder, relapsed or intolerable patients to previous interferon therapy. Patients were divided into a drug-interval changing study and a daily continual medication control group. Drug-interval changing protocol with gradual lengthening of the medication interval after conversion to undetectable HBV-DNA in serum and reduction of serum aminotransferase to normal level was monitored monthly.RESULTS:
Before treatment, 15 patients of the drug-interval change group and 11 patients of the daily medication group were similar in laboratory and pathologic findings. Mean follow-up periods were 12.8 moths and 11.4 months respectively. HBeAg seroconversion rate was higher in patients in the daily medication group (86.7% vs. 40.0%, p<0.05). The odds of loss of HBeAg, development of anti-HBe, and suppression of HBV-DNA are about 11 times, 7 times, and 8 times higher in the drug-interval change group compared with the daily medication group, respectively (p<0.05).CONCLUSION:
Drug-interval lengthening method was effective in long-term suppression of viral replication with low cost.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Follow-Up Studies
/
Interferons
/
Lamivudine
/
Hepatitis
/
Hepatitis B
/
Hepatitis B e Antigens
/
Moths
Type of study:
Practice guideline
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
The Korean Journal of Hepatology
Year:
2000
Type:
Article
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