Clinical characteristics of vitamin D deficiency rickets in infants and preschool children / 소아과
Korean Journal of Pediatrics
;
: 152-157, 2010.
Article
in Korean
| WPRIM
| ID: wpr-125484
ABSTRACT
PURPOSE:
Vitamin D deficiency rickets is a significant public health problem that results from insufficient exposure to sunlight and inadequate vitamin D supplementation. The purpose of this study is to identify the clinical characteristics of vitamin D deficiency rickets in infants.METHODS:
Data of 35 infants diagnosed as vitamin D deficiency rickets at Sanggye-Paik Hospital, Seoul, Korea, from March 2007 to May 2009 were reviewed. Children with plasma 25-hydroxyvitamin D levels <15 ng/mL and 15-30 ng/mL were considered to have vitamin D deficiency and vitamin D insufficiency, respectively.RESULTS:
Thirty-five infants (22 boys, 13 girls) were diagnosed with rickets. Mean age at diagnosis was 7.4+/-7.1 months (range 0.1-29.8 months). Eighteen infants (51%) were vitamin D deficient and seventeen infants (49%) were insufficient. Twenty-eight of all (80%) diagnosed as subclinical rickets. Twenty-nine infants (83%) were below the age of 12months. Twenty infants (57%) had breastfed and ten infants (29%) had iron deficiency anemia. Nine of breastfed infants (45%) were vitamin D deficient and ten of their mothers were vitamin D insufficient. Overall, radiographic evidence of rickets was present in 93% of the cases. Radiographic sign of rickets was evident even in vitamin D insufficient state.CONCLUSION:
It is important for the clinician to screen for subclinical vitamin D deficiency rickets in inadequately supplemented infants by pairing 25-hydroxyvitamin D levels with wrist radiographs. A nationwide epidemiological study of vitamin D deficiency rickets must be conducted and evidence-based national guidelines must be defined to prevent rickets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Rickets
/
Sunlight
/
Vitamin D
/
Vitamin D Deficiency
/
Vitamins
/
Wrist
/
Epidemiologic Studies
/
Public Health
/
Anemia, Iron-Deficiency
Type of study:
Practice guideline
/
Observational study
/
Prognostic study
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2010
Type:
Article
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