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Prognosis and Predictive Factors according to Extent of Involvement in Necrotizing Enterocolitis among Very Low Birth Weight Infants
Neonatal Medicine ; : 98-104, 2015.
Article in Korean | WPRIM | ID: wpr-125634
ABSTRACT

PURPOSE:

This study aimed to evaluate the prognosis of necrotizing enterocolitis (NEC) according to the extent of involvement, among very low birth weight infants. Furthermore, the predictive factors for extent of involvement were evaluated.

METHODS:

Medical records of all newborns with surgically treated NEC admitted to the neonatal intensive care unit of Seoul National University Children's Hospital between 2005 and 2013 were reviewed. Infants were grouped according to the extent of involvement of NEC isolated segment involvement (ISI, n=31) and multi-segment involvement (MSI, n=17). We evaluated the clinical characteristics, outcomes, and pre-operative factors according to symptoms, laboratory and radiologic findings.

RESULTS:

The incidence of small for gestational age was significantly higher in the MSI than ISI group (12.9% vs. 41.2%, P=0.036). The length of resected bowel was significantly longer (1.7 cm vs. 8 cm, P=0.010), and the incidence of short bowel syndrome (SBS) (0% vs. 23.1%, P=0.023) and mortality (3.2% vs. 23.5%, P=0.047) were significantly higher in the MSI than ISI group. However, there was no significant difference between the two groups in terms of high-output stoma, time of full enteral feeding, extrauterine growth retardation, changes of z-score of body weight between admission and discharge and reoperation. Portal vein gas detected by ultrasonography was the only statistically significant predictive factor of extent of involvement (odds ratio=13.237, P=0.029).

CONCLUSION:

SBS and mortality were higher in MSI NEC compared to ISI NEC. However, there was no difference in the time of full enteral feeding and growth between the two groups. Portal vein gas detected by ultrasonography maybe a predictive factor of extent of NEC.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Portal Vein / Prognosis / Reoperation / Short Bowel Syndrome / Body Weight / Intensive Care, Neonatal / Medical Records / Incidence / Mortality / Ultrasonography Type of study: Diagnostic study / Incidence study / Prognostic study Limits: Humans / Infant / Infant, Newborn Country/Region as subject: Asia Language: Korean Journal: Neonatal Medicine Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Portal Vein / Prognosis / Reoperation / Short Bowel Syndrome / Body Weight / Intensive Care, Neonatal / Medical Records / Incidence / Mortality / Ultrasonography Type of study: Diagnostic study / Incidence study / Prognostic study Limits: Humans / Infant / Infant, Newborn Country/Region as subject: Asia Language: Korean Journal: Neonatal Medicine Year: 2015 Type: Article