Effectiveness of Ondansetron and Midazolam in the Prevention of PONV after Thyroidectomy / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 344-349, 2007.
Article
in Korean
| WPRIM
| ID: wpr-125697
ABSTRACT
BACKGROUND:
The purpose of this study was to investigate the effectiveness of ondansetron and midazolam in the prevention of PONV after thyroidectomy.METHODS:
One hundred nineteen women undergoing thyroidectomy under general anesthesia were randomized to receive midazolam 0.075 mg/kg (Group M, n = 41), ondansetron 4 mg (Group O, n = 39), or normal saline 10 ml (Group C, n = 39) intravenously. The incidence and severity of nausea, vomiting, and pain were assessed as 6 and 24 h after the end of surgery.RESULTS:
The incidence of PONV was 34% in Group M, 46% in Group O, and 64% in Group C, which showed a significant difference between Group C and Group M, but not Group O. However, there were no significant differences between groups in pain scores and the incidence of sedation.CONCLUSIONS:
We recommend the use of midazolam as an effective antiemetic after thyroidectomy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroidectomy
/
Vomiting
/
Midazolam
/
Incidence
/
Ondansetron
/
Postoperative Nausea and Vomiting
/
Anesthesia, General
/
Nausea
Type of study:
Controlled clinical trial
/
Incidence study
/
Prognostic study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2007
Type:
Article
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