The Younger Patients Have More Better Prognosis in Limited Disease Small Cell Lung Cancer / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 274-281, 2016.
Article
in English
| WPRIM
| ID: wpr-125741
ABSTRACT
BACKGROUND:
Factors associated with the prognosis of patients with small cell lung cancer (SCLC) is relatively unknown, than of those with non-small cell lung cancer. This study was undertaken to identify the prognostic factors of SCLC.METHODS:
The medical records of 333 patients diagnosed with SCLC at tertiary hospital from January 1, 2008, to December 31, 2012 were retrospectively reviewed. Patients were categorized by age (≤65 years vs. >65 years) and by extent of disease (limited disease [LD] vs extensive disease [ED]). Overall survival and progression free survival rates were determined. Factors associated with prognosis were calculated using Cox's proportional hazard regression model.RESULTS:
Most baseline characteristics were similar in the LD and ED groups. Eastern Cooperative Oncology Group (ECOG) performance status (PS), first chemotherapy regimen, and prophylactic cranial irradiation (PCI) differed significantly in patients with LD and ED. Mean ECOG PS was significantly lower (p65 years) patients, but prognosis in the ED group was unrelated to age.CONCLUSION:
This study showed that overall survival (OS) was significantly improved in younger than in older patients with LD-SCLC. Univariate and multivariate analyses showed that age, PCI and the sum of cycles were significant predictors of OS in patients with LD-SCLC. However, prognosis in the ED group was unrelated to age.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Medical Records
/
Multivariate Analysis
/
Retrospective Studies
/
Cranial Irradiation
/
Carcinoma, Non-Small-Cell Lung
/
Disease-Free Survival
/
Drug Therapy
/
Small Cell Lung Carcinoma
/
Tertiary Care Centers
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS