Clinical characteristics of acute Q fever in Daegu area / 대한내과학회지
Korean Journal of Medicine
;
: 404-411, 2010.
Article
in Korean
| WPRIM
| ID: wpr-125932
ABSTRACT
BACKGROUND/AIMS:
Although only a few sporadic cases of Q fever have been reported in Korea, a total of 13 cases have been seen in our area. We performed this study to evaluate the clinical characteristics of these cases of acute Q fever.METHODS:
Demographic features, clinical manifestations, laboratory and radiologic findings, and therapeutic outcomes of all cases were evaluated. Q fever was diagnosed using an indirect micro-immunofluorescence assay (MIFA) and polymerase chain reaction (PCR).RESULTS:
A total of 13 patients with acute Q fever seen from January 2006 to August 2008 at three teaching hospitals in the Daegu Metropolitan City area were enrolled. The mean age was 49 years old (range, 24~76), and the male to female ratio was 112. Six (46.2%) cases had a history of animal contact. Fever (100%) was the most common manifestation, followed by myalgia (84.6%), headache (61.5%), anorexia (61.5%), and chills (61.5%). All cases were diagnosed with high titers of anti-phase II antibody (IgM> or = 150, IgG> or =1200) and positive nested PCR for the 27-kDa OMP com-1 gene of Coxiella burnettii in the blood. In three cases, liver biopsies revealed the presence of compact fibrin-ring granulomas. No characteristics of pneumonia were diagnosed on chest X-rays. The predominant presentation was acute febrile illness with hepatitis, including three cases (27.3%) of severe cholestatic hepatitis. The most frequently used antimicrobial agent was doxycycline (84.6%), followed by azithromycin (7.7%).CONCLUSIONS:
Acute Q fever may be added to the list of differential diagnosis of patients with acute febrile illness and hepatitis in the Daegu Metropolitan City area.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Q Fever
/
Thorax
/
Biopsy
/
Anorexia
/
Polymerase Chain Reaction
/
Doxycycline
/
Azithromycin
/
Coxiella
/
Chills
Type of study:
Diagnostic study
Limits:
Animals
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2010
Type:
Article
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