Effects of MK-801 (dizocilpine) on Brain Cell Membrane Function and Energy Metabolism in Experimental Escherichia coli Meningitis in the Newborn Piglet
Journal of Korean Medical Science
;
: 236-241, 2003.
Article
in English
| WPRIM
| ID: wpr-126076
ABSTRACT
We evaluated the efficacy of non-competitive N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) as an adjuvant therapy in experimental neonal bacterial meningitis. Meningitis was induced by injecting 10(6) colony forming units of Escherichia coli into the cisterna magna. MK-801 3 mg/kg was given as a bolus intravenous injection, 30 min before the induction of meningitis. MK-801 did not down-modulate the inflammatory parameters, such as increased intracranial pressure, cerebrospinal fluid (CSF) leukocytosis, increased lactate and TNF-alpha levels in the CSF, and hypoglycorrhachia observed in the meningitis group. MK-801 did not significantly attenuate the elevated glutamate concentration in the CSF. However, MK-801 showed some neuroprotective effects as evidenced by significant attenuation of cerebral lipid peroxidation products (conjugated dienes) and increase of brain high-energy phosphate compounds (ATP and PCr). Improvement in cerebral cortical cell membrane Na+, K+ -ATPase activity did not reach a statistical significance. These results suggest that MK-801 was effective in ameliorating brain injury in neonatal bacterial meningitis, although it failed to attenuate the inflammatory responses.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Swine
/
Blood Glucose
/
Brain
/
Random Allocation
/
Cell Membrane
/
Cerebral Cortex
/
Dizocilpine Maleate
/
Tumor Necrosis Factor-alpha
/
Neuroprotective Agents
/
Glutamic Acid
Limits:
Animals
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2003
Type:
Article
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