The Relationship Between Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes / 당뇨병
Korean Diabetes Journal
;
: 485-493, 2009.
Article
in Korean
| WPRIM
| ID: wpr-126156
ABSTRACT
BACKGROUND:
The incidence of type 2 diabetes mellitus is increasing annually and patient mortality is high. Coronary artery calcification is a predictor of coronary artery disease. Cardiovascular events, which are the main cause of death in type 2 diabetes patients, may be preventable by addressing risk factors associated with coronary artery calcification. We examined the relationships between coronary artery calcification, lipid profiles, and apolipoprotein levels.METHODS:
We calculated the coronary calcium scores (CCS) of 254 subjects with type 2 diabetes (113 males, 141 females) via multi-detector row computed tomography (MDCT). Height, body weight, blood pressure, HbA1c, c-peptide, lipid profile and apolipoprotein were assessed concurrently.RESULTS:
In patients with type 2 diabetes, Agatston score and apolipoprotein A-1 were significantly negatively correlated in both males and females (males P = 0.015, females P = 0.021). The negative correlation between Agatston score and apolipoprotein A-1 was retained for the entire patient sample after adjustments for age and sex (P = 0.022). Stepwise multiple regression anaylses with the Agatston score as the dependent variable indicate that apolipoprotein A-1 is a independent predictor (beta coefficient = -0.047, 95%CI = -0.072 ~ -0.021, P < 0.001) of coronary artery calcification.CONCLUSION:
The results of our study suggest that apolipoprotein A-1 is a useful independent indicator of coronary artery calcification.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins
/
Blood Pressure
/
Body Height
/
Coronary Artery Disease
/
C-Peptide
/
Cardiovascular Diseases
/
Calcium
/
Incidence
/
Risk Factors
/
Cause of Death
Type of study:
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Diabetes Journal
Year:
2009
Type:
Article
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