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Expression of Sialosyl-Tn Antigen in Breast Cancer & Its Correlation with Prognostic Parameters / 한국유방암학회지
Journal of Korean Breast Cancer Society ; : 208-214, 1998.
Article in Korean | WPRIM | ID: wpr-126313
ABSTRACT
To determine whether the expression of Sialosyl-Tn antigen may have its putative relationship as an established or potentially useful clinicopathologic prognostic parameter in breast cancer, we evaluated 110 patients with invasive breast carcinoma, using formalin-fixed, paraffin-embedded tissue sections. STn antigen was detected by the HB-STn antibody using an avidin-biotin-peroxidase method. The parameters studied were tumor size, nodal status, stage, histologic grade, ER/PR expression, DNA ploidy and S-phase fraction. STn expression was observed in 42 patients (38.2%) with breast cancer. The expression rate of STn was associated with axillary node metastasis. A tendency towards an association between STn expression and tumor size or TNM stage. There was no relationship between STn expression and histologic grade, ER/PR expression, DNA ploidy and S-phase fraction. We conclude that the detection of STn expression may be useful for predicting lymph node metastasis.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Ploidies / Breast / Breast Neoplasms / DNA / Lymph Nodes / Neoplasm Metastasis Type of study: Prognostic study Limits: Humans Language: Korean Journal: Journal of Korean Breast Cancer Society Year: 1998 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Ploidies / Breast / Breast Neoplasms / DNA / Lymph Nodes / Neoplasm Metastasis Type of study: Prognostic study Limits: Humans Language: Korean Journal: Journal of Korean Breast Cancer Society Year: 1998 Type: Article