Comparison of Prevention for Acute Rejection in Renal Transplantation between Mycophenolate Mofetil(MMF) and Azathioprine / 대한신장학회잡지
Korean Journal of Nephrology
;
: 117-122, 2002.
Article
in Korean
| WPRIM
| ID: wpr-126470
ABSTRACT
BACKGROUND:
Acute renal allograft rejection is not only risk factor of chronic rejection but is also a significant cause of graft loss and patient death. MMF has been shown to reduce the incidence and severity of acute rejection.METHODS:
To compare the risk of acute rejection and side effects of MMF with azathioprine(AZA), a total of 108 patients, who received living transplants, were divided in two groups MMF(n=48) and AZA group(n=60). Cyclosporin microemulsion(Neoral) and steroid were administered concomitantly to all patients.RESULTS:
The MMF group was significantly lower rate of acute rejection compared with AZA group during the first 3 months after renal transplantation(14.6% vs 30.0%, p=0.005). 54.5% of patients in the MMF group and 44% in the AZA group were treated only with steroid pulsing for acue rejection. 45.5% in the MMF group, compared to 56% in the AZA group, required OKT3 or Atgam for treatment of severe acute rejection, the difference is not significant. Treatment failure occurred among 31.3% of the MMF group compared with 55% in the AZA group(p=0.013). Serum creatinine of 6 months after transplantation was significantly lower in the MMF group than in the others(1.31+/-.27 vs 1.50+/-.28 mg/dL, p=0.017). The incidence of opportunistic infection was similar in both groups. Gastrointestinal side effects were more common in the MMF group 14.6% than in the AZA group 3.3%(p=0.035), while leukopenia was more common in the AZA group 21.7% than in the MMF group 4.3%(p=0.017).CONCLUSION:
MMF reduced the incidence of acute rejection without notable side effects. Long-term follow up will be needed to establish the protective effect of MMF against immunological attack.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Azathioprine
/
Opportunistic Infections
/
Incidence
/
Risk Factors
/
Follow-Up Studies
/
Kidney Transplantation
/
Muromonab-CD3
/
Cyclosporine
/
Treatment Failure
/
Transplants
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2002
Type:
Article
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