DNA Gains and Losses of Chromosome in Laryngeal Squamous Cell Carcinoma Using Comparative Genomic Hybridization
Yonsei Medical Journal
;
: 949-954, 2008.
Article
in English
| WPRIM
| ID: wpr-126744
ABSTRACT
PURPOSE:
A larynx squamous cell carcinoma (LSCC) is one of the most common forms of cancer and may exhibit various complex karyotypes. MATERIALS ANDMETHODS:
We used comparative genomic hybridization (CGH) to analyze DNA gains and losses in 15 squamous cell carcinomas that consisted of 4 glottic, 10 supraglottic, and 1 transglottic localization samples.RESULTS:
The majority of the chromosomal alterations detected were gains 3 samples of LSCCs revealed high level amplification, while 6 samples displayed gains in various chromosomal regions (17p, 3p, 4p, 5p, 6q, 8p, 9p, 14q, 18p and Xq). One sample was found to have losses (chromosomes 15q and 22q) and 5 had normal CGH profiles.CONCLUSION:
Many of these gained regions (4p, 5p, 8p, 10q, 18q and Xq) were novel sites, which may harbor oncogene(s) that potentially play an important role in squamous cell tumorigenesis and progression at supraglottic localizations.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA, Neoplasm
/
Carcinoma, Squamous Cell
/
Laryngeal Neoplasms
/
Chromosome Aberrations
/
Comparative Genomic Hybridization
/
Karyotyping
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2008
Type:
Article
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