beta-Fibrinogen Gene -455 G/A Polymorphism in Korean Ischemic Stroke Patients
Journal of Clinical Neurology
;
: 17-22, 2008.
Article
in English
| WPRIM
| ID: wpr-126850
ABSTRACT
Background and Purpose:
We investigated the relationship between the beta-fibrinogen gene (FGB) -455 G/A polymorphism and plasma fibrinogen levels in Korean ischemic stroke patients. We also determined whether the frequency of the -455 G/A polymorphism differed between two subtypes of noncardioembolic stroke large-artery atherosclerosis (LAA) and small-vessel occlusion (SVO).Methods:
A total of 267 patients with noncardioembolic stroke were enrolled. Plasma fibrinogen and other risk factors for stroke were evaluated. FGB -455 G/A genotypes were determined by polymerase chain reaction with restrictive enzyme Hae III and automatic DNA sequencing.Results:
The FGB -455 G/A polymorphism was significantly associated with an elevated plasma fibrinogen level (p<0.001). The frequency of the A allele in Korean stroke patients was 16.7%. However, the frequency of the -455 G/A polymorphism did not differ between LAA and SVO.Conclusions:
The plasma fibrinogen level might be affected by the -455 G/A polymorphism in noncardioembolic stroke patients. However, the LAA and SVO subtypes of ischemic stroke were not affected by the -455 G/A polymorphism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Fibrinogen
/
Polymerase Chain Reaction
/
Risk Factors
/
Sequence Analysis, DNA
/
Stroke
/
Alleles
/
Atherosclerosis
/
Genotype
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2008
Type:
Article
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