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Efficacy of a Topical Gelatin-Thrombin Matrix Sealant in Reducing Postoperative Drainage Following Anterior Cervical Discectomy and Fusion
Asian Spine Journal ; : 909-915, 2015.
Article in English | WPRIM | ID: wpr-126909
ABSTRACT
STUDY

DESIGN:

Retrospective fusion level(s)-, age-, and gender-matched analysis.

PURPOSE:

To determine whether the application of a topical gelatin-thrombin matrix sealant (Floseal) at the end of anterior cervical discectomy and fusion (ACDF) can reduce the amount of postoperative hemorrhage. OVERVIEW OF LITERATURE The effect of the matrix sealant in decreasing postoperative hemorrhage following ACDF has not been reported.

METHODS:

Matrix sealant was (n=116, study group) or was not applied (n=58, control group) at the end of ACDF. Patients were selected by 12 matching criteria of fusion level(s), age, and gender. Seven parameters described below were compared between the two groups.

RESULTS:

The total drain amount for the first 24 hours (8+/-9 versus 27+/-22 mL), total drain amount until the 8-hour drainage decreased to < or =10 mL (8+/-10 versus 33+/-26 mL), and the total drain amount until 6 AM on the first postoperative day (7+/-8 versus 24+/-20 mL) were significantly lower in the study group than the control group (all p<0.001). The time for the 8-hour drainage to decrease to < or =10 mL was significantly lower in the study group (10+/-5 versus 26+/-14 hours, p<0.001). The 8-hour drainage decreased to < or =10 mL on the operation day in most patients (88%) in the study group versus mostly on the first (48%) or second (33%) postoperative day in the control group (p<0.001). The total drain amount until 6 AM on the first postoperative day was 0 mL in 43% of patients in the study group and in 7% in the control group (p<0.001). No patient in either group required hematoma evacuation.

CONCLUSIONS:

Application of the topical matrix sealant at the end of ACDF can significantly reduce the amount of postoperative hemorrhage.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Spinal Fusion / Cervical Vertebrae / Drainage / Retrospective Studies / Diskectomy / Postoperative Hemorrhage / Hematoma / Hemostasis Type of study: Observational study Limits: Female / Humans Language: English Journal: Asian Spine Journal Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spinal Fusion / Cervical Vertebrae / Drainage / Retrospective Studies / Diskectomy / Postoperative Hemorrhage / Hematoma / Hemostasis Type of study: Observational study Limits: Female / Humans Language: English Journal: Asian Spine Journal Year: 2015 Type: Article